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Marijuana Affects Food Intake and Arousal

Is the stereotypical hungry cannabis smoker watching tv while sitting on the couch proven by science?

Cannabinoids modulate energy homeostasis and decrease cognitive arousal, possibly by acting on hypothalamic neurons including those that synthesize melanin-concentrating hormone (MCH) or hypocretin/orexin.

Marijuana Affects Food Intake and ArousalUsing patch-clamp recordings, new research compared the actions of cannabinoid agonists and antagonists on identified MCH or hypocretin neurons in green fluorescent protein-expressing transgenic mice. The cannabinoid type-1 receptor (CB1R) agonist depolarized MCH cells and increased spike frequency; in contrast, WIN55,212,2 hyper polarized and reduced spontaneous firing of the neighboring hypocretin cells, both results consistent with reduced activity seen with cerebral cannabinoid infusions.

These effects were prevented by AM251, a CB1R antagonist, and by tetrodotoxin, suggesting no post synaptic effect on either neuron type. In MCH cells, depolarizing WIN55,212,2 actions were abolished by the GABAA receptor antagonist bicuculline, suggesting that the CB1R-mediated depolarization was attributable to reduced synaptic GABA release.

WIN55,212,2 decreased spontaneous IPSCs, reduced the frequency but not amplitude of miniature IPSCs, and reduced electrically evoked synaptic currents in MCH cells. Glutamate microdrop experiments suggest that WIN55,212,2 acted on axons arising from lateral hypothalamus local inhibitory cells that innervate MCH neurons. In hypocretin neurons, the reduced spike frequency induced by WIN55,212,2 was attributable to presynaptic attenuation of glutamate release; CB1R agonists depressed spontaneous and evoked glutamatergic currents and reduced the frequency of miniature EPSCs.

Cannabinoid actions on hypocretin neurons were abolished by ionotropic glutamate receptor antagonists. Together, these results show that cannabinoids have opposite effects on MCH and hypocretin neurons. These opposing actions could help explain the increase in feeding and reduction in arousal induced by cannabinoids.

These opposing actions could help explain the increase in feeding and reduction in arousal induced by cannabinoids.

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